Millions of adults over 60 rely on familiar medications for pain, reflux, colds, or bone health, often without realizing that some of these drugs have been linked by research to potential cardiovascular concerns. The frustration comes when a pill you trust for relief quietly adds strain to an aging heart—raising blood pressure, disrupting rhythm, or contributing to other subtle changes over time. What’s more, these effects can build gradually, sometimes going unnoticed until routine checkups reveal surprises. By the end of this article, you’ll know exactly which five common categories deserve a closer look—and simple steps to discuss them with your doctor.
Why Heart Risks from Medications Matter More After 60

As we age, the heart and blood vessels naturally become less flexible, and the body processes drugs differently. Kidneys and liver function slow, meaning medications stay in the system longer. Add multiple prescriptions—a reality for many over 60—and interactions can amplify subtle effects.

Research consistently shows that certain widely used drugs carry cardiovascular warnings, especially with long-term use. The good news? Awareness and a conversation with your doctor can often lead to safer options.

Let’s dive into the five categories studies most frequently flag.
5. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Everyday pain relievers like ibuprofen (Advil, Motrin) and naproxen (Aleve) are go-to choices for arthritis and muscle aches.